Sweet taste perception starts from the interaction of a sweet molecule with residues of the sweet taste receptor (STR). Yet, how the perception of sweet taste emerges from this interaction is still not clear. Here, we reveal a potential mechanism in the initial stages of this cascade.

Electrochemical sensors and biosensors are today important analytical and monitoring tools in various fields, from agriculture and the food industry to environmental and biomedical/pharmaceutical applications.

Acyl-CoA dehydrogenase deficiency (ACAD) is an inherited and potentially fatal disorder with variable clinical symptoms. The relationship between pathogenicity and deleterious point mutations is investigated here in ACAD structures of short (SCAD) and medium-chain (MCAD) types.

Diabetes mellitus (DM) is a persistent, progressive, and multifaceted disease characterized by elevated blood glucose levels. Type 2 diabetes mellitus is associated with a relative deficit in insulin mainly due to beta cell dysfunction and peripheral insulin resistance. Metformin has been widely prescribed as a primary treatment option to address this condition.

Electrospinning is a well-known promising technique for the cost-effective and rapid fabrication of therapeutic-loaded nanofibers. Electrospun fibers have many merits that give them prospects in the production of therapeutic-loaded sutures.

Mercury is a highly toxic and potentially bioaccumulative heavy metal ion that can cause severe health problems in humans even at very low concentrations.

Cardiac troponin I (cTnI) is a specific biomarker in the diagnosis of acute myocardial infarction (AMI). In this study, a label-free electrochemical aptasensor was developed for the detection of cTnI using an aptamer probe and conductive polypyrrole (PPy)-gold nanoparticles (AuNPs) as electrode substrate.

Preparing samples for analyses is perhaps the most important part to analyses. The varied functional groups present on the surface of biopolymers bestow them appropriate adsorption properties.

The efficacy of human recombinant insulin can be affected by its aggregation. Effects of acetylation were observed on insulin structure, stability, and aggregation at 37 and 50 °C and pH of 5.0 and 7.4 with the use of spectroscopy, circular dichroism (CD), dynamic light scattering (DLS), and atomic force microscopy (AFM)

فاکتور رشد اپیدرمی یا EGFR یکی از انواع گیرنده های تیروزین کینازی است که در انواع مختلفی از سرطان ها افزایش می‌یابد و به رشد تومور های جامد کمک می‌کند. عملکرد فیزیولوژیکی EGFR ، تنظیم رشد بافت اپیتلیال و هومئوستازی است و در برخی سرطان ها میتواند محرک تومور زایی باشد.